Resident Evil Requiem Safe Combination Guide

02/27/2026

In the terrifying universe of Resident Evil Requiem, players can discover crucial advantages by successfully cracking various safes. These secured containers often hold significant rewards, such as Antique Coins that can be exchanged for vital character enhancements like a Hip Pouch for increased inventory space or a Stabilizer damage boost for Grace, an ally who frequently requires such aid. Throughout the game's eerie Care Center, numerous safes await discovery, each with its own unique combination. These codes remain consistent across all player experiences, ensuring that every player can benefit from this knowledge to secure additional resources and prepare for the challenges ahead.

Details on the Care Center's Secured Compartments

Explorers of the Care Center will encounter several locked safes, each yielding important loot upon successful entry. These include:

  • Bar and Lounge Safe: Situated in the West Wing, on the first floor, directly behind the bar counter. To open it, rotate the dial to 10 (left), then 80 (right), and finally 30 (left). Inside, players will find three Antique Coins. While in this area, remember to collect Grace's S&S M232 pistol and an additional Antique Coin from the piano stool. Beware the singing zombie, whose shrieks can disrupt aim, making players vulnerable to other threats.
  • Examination Room Safe: Located in the East Wing, accessible after unlocking the unicorn door leading to the Parlor and acquiring the keycard. The safe is found within a cabinet near a peculiar, organ-less corpse. Its combination is 30 (right), 10 (left), and 50 (right). This safe also yields three Antique Coins. The code for this safe can be found on a document behind the area where the 'Chunk' enemy appears, near the Lead Researcher's Office. Additionally, an already open safe in the Waiting Room, just past the East Wing Lobby, contains a few more Antique Coins.
  • Basement Safe: This safe becomes accessible later in the game, after a character switch between Leon and Grace. It is near the entrance to the Inspection area, which is initially blocked by a forklift. Players must power up a door adjacent to the Furnace room using a joint plug. Proceed through the corridor into the forklift area, and a side room will house this safe. The combination is 60 (right), 40 (left), and 80 (right). Contents include handgun ammunition and a 'Racoon Roundup' map, which helps locate Mr. Raccoon Memoriam statues within the Care Center. Leon discovers this code during his exploration of the attic.
  • Sterilization Chamber Safe: Found significantly later in the game, in the northern section of the Sterilization Chamber. This occurs during a segment where Grace attempts to open the central refining system door. The sequence for this safe is 10 (right), 90 (left), and 20 (right). Inside, players will discover handgun ammunition, a medical injector, and a molotov cocktail.
  • Monitor Control Room Safe: Also located in a later section of the game, specifically in the Monitor Control Room, adjacent to the Lobby. The combination for this safe is 50 (left), 60 (right), and 80 (left). Opening it reveals an empty bottle, a bottle of acid, and another medical injector.

Mastering these safe combinations is more than just a task; it's a strategic element that significantly influences a player's survival and progression in Resident Evil Requiem. The careful collection of Antique Coins and other supplies obtained from these safes can mean the difference between overcoming the game's formidable challenges and succumbing to its horrors. This meticulous exploration and puzzle-solving aspect not only deepens the immersive experience but also empowers players to customize their gameplay, making each encounter more manageable and enhancing their chances of success in this thrilling horror adventure.